This is a collection of programs, scripts and descriptions to produce results in various publications. You can get the publications from the publication section of this webpage. Some of the code is relatively well documented, some isn’t. Feel free to use and modify the programs any way you want. If you need help understanding certain programs, I will try to help. But my time is limited, and for a lot of the old programs, I might not even remember anymore what exactly I did. That’s especially true for anything Matlab or Fortran since I haven’t used either in years.
Note that some of the files are hosted on my github site due to some strange file restrictions by UGA.
TB Superspreader analysis – A file containing the R code performing analysis of various datasets looking for signatures of superspreading/supercoughing in TB patients. The manuscript describing this work is currently under review.”
TB-MAC UGA Model – A file containing the R code and description of the model that was used by us to produce the results described in a multi-model project on TB intervention analysis. The results are described in Houben et al. (2016) Lancet Global Health.”
TB Persistence – A collection of R scripts to run the simulations described in our 2014 PLoS One publication “Modeling the potential impact of host population survival on the evolution of M. tuberculosis latency.”
gapjunction.nlogo – An agent-based simulation, written for the freely available Netlogo platform. The code simulates gap junction mediated antigen transport during the local spread of virus and clearance by CTL. The simulation is described and used in Handel et al. 2009 JRSI.
populationmodel.m – A Matlab program that simulates the evolution of a bacterial population in repeated exponential growth and serial dilution cycles. A version of this code was used in Handel and Rozen 2009 BMC Evo Bio. Note that to run the program, you will need to also install the freely available lightspeed collection of Matlab functions.
compensatorymutation.m, SIS3strainsteady_prob.f90, SIS3strainsteady_time.f90 – (sparsely documented) Matlab and Fortran programs to simulate the evolution and spread of drug resistance through compensatory mutations. Details about the mathematical model can be found in Handel et al (2006) PLoS Comp Bio.